These changes were then compared with those from C3-deficient mice, which confirmed the involvement of C3a. This trained immunity was further validated in ex vivo experiments using primary alveolar ...

Results The GCPM ecosystem coordinates a unique immunosuppressive pattern distinct from that of primary GC, which is dominated by a stroma-myeloid niche composed of SPP1+tumour-associated macrophages ...

The biotechs teamed up to develop a method to engineer immune cells called macrophages to target solid tumors. Weekly dosing of the therapy, dubbed CAR-M, shrank lung and liver tumors in mice ...

Plasma-derived human C3a (hC3a) significantly triggered ERK1/2 phosphorylation in CHO-K1 cells (Figures 1A, C), confirming the expression of endogenous C3aR in these cells . A significant reduction in ...

Objective: Emerging evidence suggests that C3aR (C3a anaphylatoxin receptor) signaling has protective roles in various inflammatory-related diseases. However, its role in atherosclerosis has been ...

M2 macrophages (resolving, apoptotic cell and damaged molecule clearing) are induced by IL-4 and characterized by arginase and anti-inflammatory cytokine IL-10 production. Complement components C3a, ...

M2 macrophages promote fibroblast differentiation and fibrosis formation through TGF-β1 production. 17 We have also found that interferon-γ from T cells could stimulate monocyte chemoattractant ...

No difference in the fraction (%) of neutrophils (C) or macrophages (D) in the choroid 4 h after intravitreous injection of C3a or C5a was observed compared with PBS. In the laser-injury model, we ...