Macrophages react to microbial and endogenous danger signals by activating a broad panel of effector and homeostatic responses. Such responses entail rapid and stimulus‐specific changes in gene ...

Background: Activated macrophages contribute to the pathogenesis of vascular disease. Vein graft failure is a major clinical problem with limited therapeutic options. PCSK9 (proprotein convertase ...

As reparative macrophages, M2 macrophages play a crucial role in suppressing inflammatory responses and facilitating tissue repair and wound healing (37, 38). They are characterized by their ability ...

While macrophage glycolysis was shown to increase significantly in advanced lesions, their phagocytic activity seems to undergo regression, ... We also obsd. a clear difference in early- and ...

Macrophages play a central role in the development of atherosclerotic cardiovascular disease (ASCVD), which encompasses coronary artery disease, peripheral artery disease, cerebrovascular disease, and ...

FOLR2 + macrophages are an important component in the initiation of antitumor immunity (Nalio Ramos et al., 2022). In the M_C2 subpopulation, TREM2, FN1, C3, CXCR4, and SPP1 are highly expressed. It ...

BCAT1+ macrophages and HIBADH+ tumor cells were significantly upregulated in the short term response samples and had certain BCAA metabolism interaction. Through co-culture experiments of cells, we ...

Bexmarilimab, a first-in-class macrophage checkpoint inhibitor, blocks Common lymphatic and vascular endothelial receptor-1 (Clever-1) to enhance macrophage antigen presentation and T cell activation.

Inflammatory Macrophage-Targeted Atherosclerosis Treatment by miRNA-Delivered, MRI-Visible, and Anti-Inflammatory Nanomedicine. Click to copy article link Article link copied! Xiaodan Li. Xiaodan Li.

Macrophages are a pivotal component of the immune system, known for their versatility and essential roles in development, tissue repair, and immune responses. In the context of cancer, macrophages ...