Overexpression of HDAC6 in mice results in a significant thickening of the corneal epithelium. Mechanistic studies reveal that HDAC6 overexpression disrupts mitotic spindle orientation and positioning ...

Mitotic spindles are essential for correct segregation of genetic material during cell division. Whereas microtubules represent the main building blocks of mitotic spindles, presence of actin ...

Cells increase microtubule dynamics to make large rearrangements to their microtubule cytoskeleton during cell division. Changes in microtubule dynamics are essential for the formation and function of ...

and dynamically changes its subcellular localization from the interphase nucleus to the mitotic/meiotic spindle poles and the mitotic cell cortex. At these locations, NuMA acts as a key structural hub ...

The orientation of endothelial cell division is tightly regulated during the earliest stages of blood vessel formation in response to morphogenetic cues and the controlled orientation of the mitotic ...

A structure of protein filaments called the mitotic spindle hooks on to the centromere and begins to contract. This pulls the sister chromatids apart, slowly moving them to opposite poles of the cell.

Meiotic spindles in mouse oocytes form ‘inside‐out’, ending with a barrel‐shaped pole. Shifting spindles towards a mitotic‐like ‘outside‐in’ mode leads to severe chromosome alignment defects, ...

Three microtubule nucleation pathways function in mitotic cells to contribute microtubules to the assembling spindle, namely the centrosome-, chromatin- and microtubule-mediated pathways.

Many millions of times per day, football-shaped structures called mitotic spindles form within the body’s cells as they prepare ... “This is a way by which the cell can tune the amount of force it ...