为明确 B 细胞在抗肿瘤免疫中的作用机制，研究人员以 IgMi 小鼠和 Blimp-1 BcKO 小鼠为模型，探究阻断浆细胞分化的影响。发现抑制浆细胞分化可增强 B 细胞抗原呈递，激活 T 细胞免疫。该研究为肿瘤免疫治疗提供了新方向。 论文解读 在肿瘤免疫领域，B 细胞的 ...

Figure 1: Blimp-1-dependent gene-expression changes during plasma cell differentiation. Figure 2: Identification of target genes regulated by Blimp-1. Figure 3: Function of activated and repressed ...

Figure 6: Loss of XBP-1 leads to diminished Igh expression and UPR activity. Beyond the UPR, the targets of Blimp-1 and XBP-1 were largely independent, suggestive of distinct functions in PC biology.

A large blimp developed by the Chinese military has been spotted for the first time at a remote base in the desert of northwestern China, exclusive new satellite imagery obtained by CNN shows.

The sleek and futuristic vessel looks much like any other superyacht coasting across the ocean, except for the incredible blimp stationed on its upper deck, equipped with technology that would ...