The groups of patients most likely to present in primary care with an oral bisphosphonate associated osteonecrosis of the jaws are described. The factors most likely to predispose to development ...

Thus, patients continue to be exposed to the pharmacologic effects of bisphosphonate activity long after they stop taking the medication. The long-term safety and efficacy of bisphosphonate ...

In the course of evaluating the optimal duration of bisphosphonate treatment the FDA found little benefit of treatment beyond 5 years. [1,2] Moreover, examination of studies where bisphosphonates ...

This is a retrospective study of 20 AYA patients—34 affected hips—who received zolendronic acid 5 mg intravenously each year along with oral alendronate 70 mg weekly for 3 years. Clinical evaluation ...

Studies show conflicting results regarding the possible excess risk of atypical fractures of the femoral shaft associated with bisphosphonate use. In Sweden, 12,777 women 55 years of age or older ...

January 8, 2008 — Temporary or permanent discontinuation of bisphosphonate therapy should be considered in patients who present with severe musculoskeletal pain, the US Food and Drug ...

Patients were identified using the SEER-Medicare linked database and followed through December 2013. Cumulative incidences of IV bisphosphonate initiation and time to discontinuation among users were ...

Despite potential side effects, bisphosphonate therapy may benefit postmenopausal women with osteoporosis by preventing fractures, according to a study published in JAMA Internal Medicine.

Back to Healio The human monoclonal antibody denosumab more effectively increases bone mass in patients with low bone mineral density or osteoporosis when compared against any bisphosphonate ...

In June 2008, the FDA requested information from all bisphosphonate drug makers related to these type of fractures. The agency said a review of the data did not show an increased risk for women ...

patient history Ongoing treatment with bisphosphonate therapy may not be needed to prevent future fractures in certain patients due to the sustained effect of the drug. In the long-term treatment ...