A genome-mining approach, combining bioinformatics analysis and chemical insight, is applied to extract an interesting new structure from an organism previously thought to have been exhaustively ...

Figure 1: Steady-state mRNA levels of genes that are regulated by Tcf1. Figure 4: Bile acid concentrations are increased in the serum, stool and urine of Tcf1 −/− mice. Figure 5: Tcf1 is a ...

† Department of Fisheries and Wildlife, Michigan State University, Room 13 Natural Resources Building, 480 Wilson Road, East Lansing, Michigan 48824, United States ‡ Department of Chemistry, ...

The binding of naphthalene (Np), 1-ethylnaphthalene (EtNp), acenaphthene (AcN), and 1-naphthyl-1-ethanol (NpOH) as guests to the aggregates of sodium cholate (NaCh), taurocholate (NaTC), deoxycholate ...

In mice, coupling generates tauro-α-muricholic acid (TαMCA), tauro-β-muricholic acid (TβMCA), and tauro-ursodeoxycholic acid (TUDCA), which are then transported and stored in the gallbladder by the ...