Mitochondrial function is also necessary for the progressive oxidation of LDL in endothelial cultures. 113 In addition, small dense LDL particles associated with central obesity are more prone to ...

Furthermore, inhibition of mitochondrial fusion via Marf, or beta-oxidation via Whd, were also able to improve mitochondrial membrane potential, muscle lipid stores and overall muscle integrity.

In this study, utilising our previously characterised eye imaginal disc tumour models (Lodge et al, 2021), we identified two muscle-specific mechanisms that contribute to muscle wasting: (1) altered ...

Long-chain fatty acid beta-oxidation disorders (lcFAOD) are a group of inherited metabolic diseases, characterized by the accumulation of disease-specific acyl-CoAs reflecting the enzyme deficiency.

Beta oxidation is a cellular biochemical reaction that produces energy from lipids. we will thoroughly examine B-oxidation of different fatty acids and how energy is produced from each fatty acid in ...

Mitochondrial uncoupling leading to ineffective energy utilisation and increased beta-oxidation of fatty acids might be a useful addition to other metabolic drugs, potentiating their effect sizes. The ...

Long Chain Fatty Acid Oxidation Disorders. Invitae. Accessed June 3, 2021. Ultragenyx Announces U.S. FDA Approval of Dojolvi™ (UX007/triheptanoin), the First FDA-Approved Therapy for the Treatment of ...