With the emergence and rapid spreading of NDM-1 and existence of clinically relevant VIM-1 and IMP-1, discovery of pan inhibitors targeting metallo-beta-lactamases (MBLs) became critical in our battle ...

The global rise of metallo-β-lactamases (MBLs) is problematic due to their ability to inactivate most β-lactam antibiotics. MBL inhibitors that could be coadministered with and restore the efficacy of ...

The drug – a combination of beta-lactam antibiotic aztreonam with beta-lactamase inhibitor avibactam – is the first monobactam/β-lactamase inhibitor combination to be cleared in the US for ...

Iterum Therapeutics plc (Nasdaq: ITRM) (the “Company” or “Iterum”), a company focused on delivering next generation oral and IV antibiotics to treat infections caused by multi-drug resistant pathogens ...

Antibiotic and other antimicrobial resistance could hamstring important medications. One Canadian initiative brings together ...

Baroud M, Dandache I, Araj GF, Wakim R, Kanj S, Kanafani Z, Khairallah M, Sabra A, Shehab M, Dbaibo G et al (2013) Underlying mechanisms of carbapenem resistance in extended‐spectrum ...

推荐意见8：推荐采用经典药动学一房室或二房室模型与一级消除公式进行美罗培南PK/PD参数计算。在已有临床可适用的PPK模型时，可根据模型通过贝叶斯反馈进行PK/PD参数计算。

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