Clusters of beta islet cells engrafted under a mouse's cornea, showing some vascularization of the implanted cells. Credit: Courtesy of Stephan Speier" />Clusters of beta islet cells engrafted under a ...

Intermittent fasting benefits adults but may harm young beta cells, increasing diabetes risk in adolescents. A recent study ...

In this type of diabetes, the immune system specifically destroys insulin-secreting beta cells in the pancreatic islets — the body's own immune system attacks its own cells (a form of autoimmune ...

More information: Esra Karakose et al, Cycling alpha cells in regenerative drug-treated human pancreatic islets may serve as key beta cell progenitors, Cell Reports Medicine (2024). DOI ...

PDX-1 is a critically important transcription factor for the insulin promoter, is absent in glucotoxic islets, and, when transfected into glucotoxic ß-cells, improves insulin promoter activity.