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Objective: To evaluate the effect of treatment with the dipeptidyl peptidase (DPP)-4 inhibitor vildagliptin on insulin sensitivity and β-cell function in subjects with impaired fasting glucose (IFG).

If regulators clear the application, the firm will begin a Phase I/II trial for RJVA-001 to assess its safety, tolerability, and initial efficacy.

Imbalances in metal ions may play a role in the development of diabetes and its complications. Can they be a novel target for ...

2007). Table 1 lists some of the GPCRs expressed by beta cells that are known to affect insulin secretion and their natural ligands. As the ligands and function of additional GPCRs are defined ...

Diabetes is a widespread health condition affecting about 415 million people worldwide. Among these cases, nearly 90% are ...

Compared with a higher-carbohydrate diet, carbohydrate-restricted intake improved the function of compromised beta-cells in ...

Mitochondria are essential for generating energy that fuels cells and helps them function. Mitochondrial defects, however, ...

Scientists from Mount Sinai Health System in New York City and City of Hope in Los Angeles have discovered a promising new ...