Further studies have shown that the expression of the key autophagy regulator protein Beclin 1 is reduced in early AD, suggesting a connection between autophagy dysregulation and AD. Although a large ...

Regulating membrane protein abundance through Lysosome Targeting Chimera (LYTAC) holds significant promise in addressing various diseases. However, the precise structural control of LYTAC molecules ...

Introduction. The pathogenesis of acute pancreatitis (AP) is complex and multifactorial and has not been fully elucidated. Impaired autophagy, abnormal activation of trypsinogen, and the increased ...

Animals were then washed three times with phosphate‐buffered saline with 2% Tween‐20 (PBST) and incubated with fluorescently labeled secondary antibody at room temperature for 1 h. Slides were viewed ...

AMPK, amp-activated protein kinase; ATG, autophagy-related gene; FIP200, focal adhesion kinase family interacting protein of 200 kDa; HOPS, homotypic fusion and protein sorting; LAMP-2, ...

The method involves fixation of tissues, typically in formalin, followed by paraffin embedding, sectioning, and staining. Specific primary antibodies targeting autophagy markers such as LC3, Beclin-1, ...