Background: The Beclin-1/Bcl-2 complex plays a pivotal role in regulating both autophagy and apoptosis in osteoblasts affected by osteoporosis. This study first investigates whether the Bushen Jianpi ...

In OSCC, several signaling pathways influence the regulation of autophagy, dictating its dual roles in tumor suppression and progression. This section explores three key pathways—mTOR, AMPK, and ...

induces autophagy. However, it is now clear that there are also TOR-independent types of regulation. For example, beclin-1 and Atg4 might be regulated by the c-Jun N-terminal kinase (JNK ...

Autophagy inhibition via chloroquine treatment or depletion of Beclin-1 or ATG-7, augmented oxidative stress induced by EoE-relevant stimuli in murine EoE, oesophageal organoids and human oesophageal ...

Aging involves gradual functional decline across various biological systems, including impaired cellular mechanisms such as ...

Besides the participation of mitochondria–lysosome contacts in organelle dynamics regulation, mitochondrial protein translation and melanogenesis, and their possible contribution to autophagy and ...

Future Microbiol. 2012;7(6):719-731.

He, H.J., Cen, X.H., Liang, Y.J., Zhong, J.M., Deng, J.H. and Jiang, Y.J. (2025) Progress in the Regulation of Lipid Metabolism by the Orphan Nuclear Receptor Nur77. Journal of Biosciences and ...

1Cellular Degradation Biology Center, College of Medicine, Seoul National University, Seoul, Republic of Korea. 2Department of Biomedical Sciences, College of Medicine, Seoul National University, ...

Neutrophil extracellular traps-mediated Beclin-1 suppression aggravates atherosclerosis by inhibiting macrophage autophagy. Front Cell Dev Biol, 2022; 10: 876147 •中国高血压联盟理事 ...

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