Cancer patients invariably develop resistance to targeted drugs, so drugmakers develop strategies to combat it before ...

Cancer patients invariably develop resistance to targeted drugs, so drugmakers develop strategies to combat it before ...

A landmark review in Nature Reviews Genetics dissects the rare and common genetic variants that shape human height. The paper explains how monogenic and polygenic factors converge on key growth ...

In-Licensing of novel activin E antibody underscores iBio’s commitment to delivering meaningful benefits to patients living ...

This work assesses the genetic interaction between the Bmp signaling pathway and the factor Numb, which can inhibit Notch signalling. It follows up on the previous studies of the group (Tian, eLife, ...

This study sought to determine whether the SOCS3/JAK/STAT3 signaling pathway, which controls macrophage polarization, contributes to the cardiotoxicity caused by PD-1/PD-L1 inhibitors. The PD-1/PD-L1 ...

Nat Rev Clin Oncol 18: 345-362. 11. Wu Q, Jiang L, Li SC, et al. (2021): Small molecule inhibitors targeting the PD-1/PD-L1 signaling pathway. Acta Pharmacol Sin 42: 1-9. 12. Bai H, Wang Z, Li M, et ...

Similarly, circRNAs such as circ_0000479 and circ_0026344 promote fibrosis, whereas circ_0000072 and circ_0000410 act as inhibitors, with certain circRNAs (e.g., circ_002178 and circ_0001246) ...

Other work has evaluated new combinatorial pathways with classic PD-1 blockade to expand response, such as LAG-3, TIGIT, and NKG2A. These treatments have been used in trials for use in metastatic CRC ...

Like Journavx, Latigo’s lead product LTG-001, and follow up candidate LTG-305, are an ion channel blockers using the Nav1.8 inhibitor pathway. Ion channel blockers selectively target peripheral nerves ...