The method for BAC manipulation that has been used most frequently in the construction of BAC transgenic mice is the original system described by Yang et al. 5 As mentioned above, several other ...

Generation and validation of BAC transgenic reporter mice to monitor p53 expression. (a) In situ hybridization of p53 mRNA using sense and antisense probes on postnatal day 1 mouse skin, P7 ...

Species: Mouse Genes: LRRK2 Mutations: LRRK2 G2019S Modification: LRRK2: Transgenic Disease Relevance: Parkinson's Disease Strain Name: B6.Cg-Tg(Lrrk2*G2019S)2Yue/J Genetic Background: A BAC construct ...

Importantly, BAC-HDL2, but not control BAC mice, accumulated polyQ-containing NIs in a pattern that was remarkably similar to that seen in HDL2 patients. The findings point to overlapping polyQ ...

[UCLA Health/Yang Lab] The new HD model is a bacterial artificial chromosome (BAC) transgenic mouse expressing full length human mutant huntingtin (mHTT) with about 120 uninterrupted CAG repeats.

Transgenic mice are commonly used in medical research. By altering their DNA, scientists can create a mouse with the specific biologic or biochemical features they'd like to study.

How UGA used transgenic mice for Alzheimer's research UGA researchers developed the world's first transgenic mouse model to study Hirano bodies, tiny structures found in nerve cells of people with ...

Species: Mouse Genes: LRRK2 Modification: LRRK2: Transgenic Disease Relevance: Parkinson's Disease Strain Name: FVB/N-Tg(LRRK2)1Cjli/J Genetic Background: BAC injected into fertilized FVB zygotes.