Transcriptomic analysis and molecular docking were used to identify potential GA-related pathways and targets for improving vitiligo. In addition, we evaluated the proliferation of B16F10 cells by PTU ...

Metastatic melanoma, also known as stage IV melanoma, is a type of skin cancer that spreads to other parts of the body. It is ...

研究人员主要运用了以下几种关键技术方法：一是细胞培养与转染技术，将不同形式的 CAV1（野生型、Y 14 E 突变体、Y 14 F 突变体）转染到 B16F10 小鼠黑色素瘤细胞中；二是 EVs 的分离与鉴定技术，通过超速离心法从细胞培养上清中分离 EVs，并利用纳米颗粒跟踪 ...

Metastatic melanoma is the most aggressive form of skin cancer. In an effort to achieve targeted therapy for metastatic melanoma, researchers recently developed a new radioactive drug that emits alpha ...

*仅供医学专业人士阅读参考近年来，免疫检查点抑制剂（ICI）在某些癌症类型中表现出令人鼓舞的效果，但大多数患者对治疗无反应或最终产生耐药性，这成为免疫治疗进一步推广的主要障碍。肿瘤细胞的内在耐药机制和肿瘤微环境（TME）里的免疫抑制性细胞共同作用，导 ...

The synthesized peptides were then tested on B16F10 melanoma-bearing mice models, following which they conducted a biodistribution analysis where the team compared tumor uptake, clearance from ...

Metastatic melanoma, also known as stage IV melanoma, is a type of skin cancer that spreads to other parts of the body. It is ...

更颠覆认知的是，被称为"脂肪燃烧酶"的CPT1A竟藏着第二重身份——它能像分子剪刀般将PD-L1送入溶酶体销毁。当研究者给小鼠注射降脂药苯扎贝特（Bezafibrate）激活CPT1A时，肿瘤体积在21天内缩小82%，联合CTLA-4抗体后甚至实现完 ...

Journal of Nuclear Medicine February 2025, jnumed.124.268857; DOI: https://doi.org/10.2967/jnumed.124.268857 ...

SHANGHAI, China I March 6, 2025 I Everest Medicines (HKEX 1952.HK, "Everest", or the "Company"), a biopharmaceutical company focused on the discovery, ...

EVM16是一款云顶新耀自研、AI算法驱动识别肿瘤新抗原的新型mRNA个性化肿瘤治疗性疫苗。 根据每位患者特有的肿瘤细胞突变，使用自主研发且具备自我迭代能力的EVER-NEO-1“妙算”肿瘤新抗原人工智能AI算法系统，识别出具有较高免疫原性的肿瘤新抗原，并设计出编码数十种肿瘤新抗原的mRNA治疗性疫苗。