More importantly, cells depleted of p190RhoGAP showed faulty temporal regulation of RhoA activity. Each of these treatments attenuated actin reorganization induced by flow. Similarly, stress fibers ...

These ABPs are intricately implicated in the initiation and advancement of prostate cancer through a complex array of intracellular processes, such as severing, linking, nucleating, inducing branching ...

This important article presents evidence for a special role of mitofusin-2, not shared with mitofusin-1, in regulating the actin cytoskeleton through calcium, RhoA, and actomyosin contractility. The ...

There are only limited data in randomised trials testing the efficacy of vitamin B for treating peripheral neuropathy and the evidence is insufficient to determine whether vitamin B is beneficial or ...

While cytoskeleton organization driving the initial formation of the B cell synapse has been studied, how the cytoskeleton supports antigen extraction remains poorly understood. Here we show that ...

Profilin and DIAPH1, which are regulated by RAP1 and RhoA, respectively, are suggested to participate in actin polymerization during B-cell activation. BCR signaling also influences contraction of the ...

Consequently, hallmarks of cancer invasion and metastasis related to RhoA, actin cytoskeleton, and/or force transmission, such as migration, extracellular matrix degradation, and Serpin B2 secretion, ...

The plasma membrane and the underlying actin cortex show dynamic interactions ... cDNAs encoding full-length ezrin, MRLC1, Eps8, anillin, p190–Rho–GAP-B, Rnd3, and RhoA were amplified by RT-PCR, fused ...

Single-particle tracking reveals that increased severing of actin ... receptor aggregation. A20 B-lymphoma cells were from ATCC. Plasmids encoding constitutively active (CA) RhoA (RhoA Q63L ...

Cucurbitacin B (CuB), a potent antineoplastic agent of cucurbitacin triterpenoids ... Collectively, our studies highlighted that the CuB-induced actin aggregation and cofilin-actin rod formation was ...