Deep learning and ATAC-seq uncover noncoding variants linked to gene regulation and disease in human liver cells.

This workflow demonstrates how to integrate motif annotation, chromVAR motif activity scoring, differential motif analysis, and motif enrichment analysis into your ATAC-seq pipeline using Signac.

Community-curated list of software packages and data resources for single-cell, including RNA-seq, ATAC-seq, etc.

Two common single-cell omics include single-cell RNA-sequencing (scRNA-seq) which profiles gene expression by capturing mRNA transcripts, and single-cell ATAC sequencing (scATAC-seq) which profiles ...

SPACE-seq 技术原理与优化 技术原理：该技术基于转座酶可及染色质测序（ATAC-seq）进行改进，通过给 Tn5 转座酶加载含有 3′多聚腺苷酸（polyA）突出端的适配体，使染色质片段带上 polyA 尾巴，进而利用标准空间转录组学试剂捕获这些片段，实现对复杂组织空间表 ...

Researchers have successfully employed an algorithm to identify potential mutations which increase disease risk in the noncoding regions our DNA, which make up the vast majority of the human genome.

“胖，是因为懒。”这句话你是不是也听过无数次？不动如山、嘴不停歇、减肥三分钟热度——仿佛体重超标这件事，只要靠毅力就能解决。但越来越多的研究在提醒我们：把肥胖简单归咎于“个人不够自律”，真的太过粗暴。

Researchers from Children's Hospital of Philadelphia (CHOP) and the Perelman School of Medicine at the University of ...

CHOP, Penn Medicine researchers use deep learning algorithm to pinpoint potential disease-causing variants in non-coding regions of the human genome: Philadelphia, Pennsylvania Mo ...

目前，人们对大剂量 AAV ...