免疫组化显示，gdnf+stz组的反应性微胶质细胞比例（iba1r%）与stz组无差异（p>0.05），均显著高于对照组，表明gdnf未能阻断stz诱导的神经炎症级联反应。 讨论部分指出，该研究首次证实AAV9介导的星形胶质细胞GDNF过表达可重塑细胞形态并部分保护认知功能，但其疗效受限于神经炎症的持续存在。

Astrocytes have a primary cell body (soma) with numerous branching processes that envelope nearby synapses ().This three-part structure is known as the tripartite synapse ().A single astrocyte can ...

Astrocytes are important glia cell type in the central nervous system. These cells can undergo transformation to a reactive state upon injury such as focal ischemic stroke (FIS). Reactive astrocytes ...

Objective Although glial cell line-derived neurotrophic factor (GDNF) is a member of the transforming growth factor-β superfamily, its function in liver fibrosis has rarely been studied. Here, we ...

A2 astrocytes produce neurotrophic factors such as GDNF and BDNF, as well as anti-inflammatory molecules. Some antidepressants inhibit the production of pro-inflammatory cytokines and promote the ...

Summary: Astrocytes, critical brain cells, are often lost in neurodegenerative diseases, but recent research highlights the promise of astrocyte transplantation to restore brain function.These ...

In adult animals, GDNF is mainly secreted by striatal neurons rather than astrocytes and microglial cells (Hidalgo-Figueroa et al., 2012). The present study also shows that GDNF mRNA levels in SH-SY5Y ...

Astrocytes, one of the most resilient cells in the brain, transform into reactive astrocytes in response to toxic proteins such as amyloid beta (Aβ) in Alzheimer’s disease (AD). However, reactive ...

To determine whether these astrocytes arose from committed neuronal progenitors, we employed Dlx5/6-Cre to deplete Tcf4 in differentiating neuronal progenitors (Batista-Brito et al, 2008). No ...

In ALS, astrocytes degenerate as the disease progresses. CNS10-NPC-GDNF is a stem cell-based therapy containing human neural progenitor cells that have been genetically engineered to produce GDNF. The ...