免疫组化显示，gdnf+stz组的反应性微胶质细胞比例（iba1r%）与stz组无差异（p>0.05），均显著高于对照组，表明gdnf未能阻断stz诱导的神经炎症级联反应。 讨论部分指出，该研究首次证实AAV9介导的星形胶质细胞GDNF过表达可重塑细胞形态并部分保护认知功能，但其疗效受限于神经炎症的持续存在。

Abstract. Neuron–astrocyte associative memory. Astrocytes, the most abundant type of glial cell, play a fundamental role in memory. Despite most hippocampal synapses being contacted by an astrocyte, ...

The astrocytes' response to neuronal signals can also change; they can modulate how they respond to neurotransmitters such as dopamine and glutamate. “Astrocytes are really big, and a single cell can ...

What’s more, these cells are everywhere. Estimates vary, but astrocytes may constitute about 20 percent of brain cells, says Kevin Guttenplan, a coauthor of one of the new studies and ...

Aluminum is a metal element with significant neurotoxicity, and there is a substantial correlation between aluminum exposure and cognitive dysfunction. Glial fibrillary acidic protein (GFAP) is widely ...

The brain also contains billions of astrocytes — star-shaped cells with many long extensions that allow them to interact with millions of neurons. Although they have long been thought to be mainly ...

This paper discusses the regulatory role of reactive astrocytes in neuroinflammation and PD neurodegeneration, as well as the reduction of neuroinflammation and the progression of PD through exercise ...

MIT researchers have now put forth a new hypothesis for how astrocytes might contribute to memory storage. The architecture suggested by their model would help to explain the brain's massive ...

Bayer subsidiary BlueRock Therapeutics has dosed the first Parkinson's disease patient in a phase 1 trial of its cell-based therapy DA01, which aims to replenish the neurons lost in people with ...