A recent publication in Genes & Diseases has delivered a compelling synthesis of the latest insights into the cellular ...

We first address the etiopathophysiology of OA and the mechanisms responsible for breakdown of the cartilage extracellular matrix. We then discuss the potential of MSCs for articular cartilage ...

These findings highlight the importance of matrix component interactions in modulating detection sensitivity and show that these effects are critical in allowing clinically relevant detection levels ...

Antibody Anti-Actin (Mouse monoclonal) BD Biosciences Cat# 612656 Loading control for western blotting (1:200) Antibody Anti-Collagen II (Mouse monoclonal) Invitrogen Cat# MA137493 Detects cartilage ...

(28−30) The primary objective of this study is to investigate the efficacy of a novel dual-network hydrogel system composed of LT-GelMA and F127DA in promoting the regeneration of ear cartilage ...

This cover highlights the article PLK1 inhibition delays mitotic entry revealing changes to the phosphoproteome of mammalian cells early in division by M. Gobran, P. Lenart and colleagues. HeLa Kyoto ...

Growth and maturation of cartilage of articular joints are dynamic processes mediated by cell fates and extracellular matrix metabolism. These processes are regulated by complex biochemical and ...

ADAMTS5 is involved in the pathogenesis of OA. As the major aggrecanase-degrading articular cartilage matrix, ADAMTS5, has been regarded as a potential target for OA treatment. We here provide an ...

Chondrogenic redifferentiation was subsequently assessed by viability, histology and quantitative analysis of cartilage matrix components by GAG Assay and RT-qPCR ... The Young’s modulus was ...

Step 4: p-cMGP is secreted into the extracellular matrix or the circulation to inhibit soft tissue calcification, VSMC (vascular smooth muscle cell) trans-differentiation into OPC (osteochondrogenic ...