This study presents an important finding on the role of GATA4 in aging and OA-associated cartilage pathology. The evidence supporting the conclusions is compelling, with rigorous in vitro and in vivo ...

is characterized by impaired extracellular matrix (ECM) synthesis and the degradation of articular cartilage. It is influenced by various factors, including aging and mechanical stress (such as ...

Progressive degeneration of articular cartilage, the subsequent decrease in joint space and osteophyte formation, as well as proteoglycans and collagen loss, extracellular matrix (ECM) mineralization, ...

Successful regeneration in articular cartilage and meniscus is challenged by the limited understanding of how these two tissues and their extracellular matrices (ECMs) initially form. This thesis ...

Changes in the extracellular matrix can lead to such chronic diseases ... in one-month-old mutant mice a central area of the articular cartilage at the head of the femur bone in the upper thigh ...

Repair of articular cartilage defects is a challenging aspect of clinical treatment. Kartogenin (KGN), a small molecular compound, can induce the differentiation of ...

Department of Chemical Engineering, National Taiwan University, No.1, Sec. 4, Roosevelt Rd., Da’an Dist., Taipei City 10617, Taiwan ...

While neutrophil extracellular traps (NETs) have been proposed to play a role in the generation of modified autoantigens and in the activation of synovial fibroblasts, it remains unknown whether NETs ...

The aim of this study was to identify gene-gene interactions (epistasis) of the articular cartilage extracellular matrix (ECM) in knee OA. Ninety-two knee OA patients and 147 healthy individuals were ...

Progressive degeneration of articular cartilage, the subsequent decrease in joint space and osteophyte formation, as well as proteoglycans and collagen loss, extracellular matrix (ECM) mineralization, ...