Hyaline cartilage consists of round chondrocytes, which are cells that produce collagen, embedded within a dense extracellular matrix (ECM). This ECM acts as a physical scaffold ... is to provide an ...

Such data somewhat support the aforementioned hypothesis. Meanwhile, our understanding of the extracellular matrix (ECM) has changed considerably over the last decade. A lot of studies have bit by bit ...

Cartilage comprises two major components, the extracellular matrix (the surrounding proteins that provide structure) and chondrocytes, the resident cell population. In OA, the health of both these ...

These particles, called extracellular vesicles, are considered attractive vehicle models for new drug therapies. But until now, researchers haven't had the complete picture of how they work.

rather than a thick matrix common to other cartilage. The cells are also highly uniform and can pack close together like bricks. Together, the cells form a springy, squishy tissue that has a bit ...

Articular cartilage was separated from the femoral heads of mice ... characterized by a marked increase in glycosaminoglycan depletion within the extracellular matrix and more advanced cartilage ...

CartiLife is indicated for the treatment of knee cartilage defects. CartiLife is under development for the treatment of articular cartilage defects. The drug candidate comprises of pellet-type ...