The regulator approved the indication based on data showing Kisqali with an aromatase inhibitor improved invasive disease-free survival versus just an aromatase inhibitor.
such as tamoxifen or aromatase inhibitors for breast cancer or androgen ablation for prostate cancer. The effects of chemotherapy-associated cardiovascular toxicity and alterations in ...
Drug-related adverse events include hand ... Sorafenib might help overcome resistance to the aromatase inhibitors in patients with hormone receptor-positive MBC who have developed resistance ...
There were more grade 3/4 drug-related adverse events, however, coming in at 18.9% in the combination arm compared to 9.7% with Opdivo, and discontinuation rates were 14.6% and 6.7%, respectively.