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生物通
19 天
精氨酸酶1通过线粒体嵴重塑和PANoptosis驱动缺血/缺氧诱导的血管功能 ...
本研究针对缺血/缺氧损伤导致的血管功能障碍这一临床难题,揭示了精氨酸酶1(Arg1)通过调控线粒体嵴结构蛋白Mic10、介导VDAC1 ...
生物通
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双效精氨酸酶抑制剂OATD-02通过代谢重编程肿瘤微环境增强抗癌免疫 ...
肿瘤微环境(TME)中L-精氨酸(L-Arg)代谢异常是免疫逃逸的关键因素。Molecure SA团队发现新型双效精氨酸酶(ARG1/ARG2)抑制剂OATD-02能 ...
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