After a drunken night in Thailand, a 29-year-old man unknowingly swallowed a 15-centimeter spoon – which remained lodged in his intestine for six months before doctors discovered it and removed it.

本研究针对母体肥胖如何通过发育编程影响子代肝脏健康这一关键科学问题，揭示了Kupffer细胞(KCs)作为'发育起源健康与疾病'(DOHaD)理论中跨代信息传递者的重要作用。研究人员通过建立母体肥胖小鼠模型，结合多组学分析和细胞命运追踪技术，发现母体高脂饮食会通过缺氧诱导因子1α(HIF1α)介导的 ...