Trained immunity is a form of innate immune cell memory that is being developed as a novel immunotherapeutic approach for cancer treatment.

Preclinical Studies Demonstrate Durable Protection Against SARS-CoV-2 Variants, Including Omicron XBB.1.5, Driven by T-Cell ...

Innate lymphoid cells, which curiously behave like T cells even though they don’t recognize specific antigens, show promise as a potential cancer therapeutic.

Hybrid immunity, through vaccines and exposure to the virus, is likely to protect people but they still need to follow Covid appropriate behaviour, says the health expert ...

More than three decades ago, the U.S. Food and Drug Administration (FDA) approved Bacillus Calmette-Guérin (BCG) as the first immunotherapy against cancer. And it is still used today to treat ...

"Interferons are a central component of the innate immune system and combat viral infections by activating hundreds of antiviral genes in cells. This likely enables bats to control viral ...

Here, we identify dual-specific tyrosine phosphorylation-regulated kinase 4 (DYRK4) as an important regulator of virus-triggered IFN-β induction and antiviral innate immunity. Overexpression of DYRK4 ...

Future investigations will be necessary to fully elucidate the connections between cholesterol metabolism and antiviral innate immunity. Globally, we have repeatedly been confronted with pandemics ...

We believe that the Research Topic will give updated insights into the dynamic fields of DNA sensing during innate antiviral immunity, and hope it will serve the purpose to encourage new researches.

While some foods can support your immune system, others may weaken it. Reviewed by Dietitian Christa Brown, M.S., RDN, LD ...

We found that PBLD deubiquitinates and stabilizes MAVS through ubiquitin-specific protease 4 (USP4) to promote antiviral innate immunity. Mechanistically, PBLD activates the transcription of USP4 via ...

Virus-induced disease contributes to significant detrimental impacts on global health and the economy. Innate immunity represents the first barrier against viral infection, where innate host-defense ...