ABSTRACT: In this work, a conceptual DFT investigation is carried out to study the electrophilic aromatic substitution reaction (SEAr) of 1,2-dimethoxybenzene and 3-(p-nitrobenzoyloxy)-but-3-en-2-one ...

Keywords: nitration, aromatic electrophilic substitution, nitroaromatics, benzene derivatives, green synthesis, ultrasound, microwave, high hydrostatic pressure Citation: Plasse KM, Mooney TR, ...

RESEARCH TRIANGLE PARK, N.C., Feb. 01, 2024 (GLOBE NEWSWIRE) -- Fennec Pharmaceuticals Inc. (NASDAQ: FENC; TSX: FRX), a commercial stage specialty pharmaceutical company, today announced that the U.S.

Heated to 380~400°C, it decomposes into phenol and ethylene. Dissolve anisole in cold concentrated sulfuric acid, and add aromatic sulfinic acid. A substitution reaction occurs at the para position of ...

Undergraduate organic chemistry courses often teach that such electrophilic aromatic substitution reactions proceed via a carbocation, known as a Wheland intermediate ... a joint computational and ...

Electrophilic aromatic substitution (EAS) ... The 1 H NMR spectrum of an isolated sample of 3 displayed only two downfield chemical shifts at 9.44 and 7.70 ppm, indicating the considerable change in ...

An approach for the direct electrophilic C–H fluorination of arenes is reported, using a palladium catalyst and mild fluorinating reagents. In the pharmaceutical industry, fluorine has long been ...

ConspectusThe classic SEAr mechanism of electrophilic aromatic substitution (EAS) reactions described in textbooks, monographs, and reviews comprises the obligatory formation of arenium ion ...