More than 80% of early human embryos contain cells with an incorrect number of chromosomes—a phenomenon called aneuploidy.

Former President Joe Biden was diagnosed with an "aggressive form" of prostate cancer that has a five-year survival rate of between 30% and 40%. The former president's prostate cancer is ...

Peer ReviewDownload a summary of the editorial decision process including editorial decision letters, reviewer comments and author responses to feedback. Aneuploidy is prevalent in cancer and ...

This aberration, previously considered a consequence of genomic instability, is now recognized as a potential driver of cancer development. Dr Suruchi Aggarwal, PhD (Human Genomics), Lead, Scientific ...

Researchers used CRISPR technology to remove entire chromosomes in melanoma, gastric cancer, and ovarian cell lines Eliminating aneuploidy compromised cancer cells' ability to form tumors ...

Healthy human cells have 23 pairs of chromosomes, but it’s been observed for over a century that the majority of cancer cells have extras. This condition is known as aneuploidy, but its exact ...

But for decades, researchers have debated whether aneuploidy promotes the growth of cancers, or is simply a side effect of cancer cells' fast growth. Such large-scale changes in DNA have been ...

Here, we present a single-cell heterogeneity-aware and transformer-guided deep learning framework to predict aneuploidy from whole slide histopathology images. First, we perform nuclei segmentation ...

Despite the detrimental consequences of aneuploidy for fitness in normal cells, it constitutes a hallmark in cancer, thus creating a paradox as its contribution to tumorigenesis. The study of the ...

Interestingly, in the flagship endometrial CPTAC study, ribosome biogenesis was one of the most strongly enriched pathways in the serous uterine cancer subtype (Dou et al., 2020), which is the one ...