In the twentieth century, amyloidologists found that amyloid fibrils were proteinaceous in origin, and by the 1960s some amyloid subunits (such as the fragments of immunoglobulins that accumulate ...

These fragments aggregate into amyloid fibrils, forming cellular inclusions that are hallmarks of HD pathology. The propensity of polyQ proteins to aggregate correlates with tract length, which ...

The kinetics of fibrillization in dilute aqueous solutions of the protein was monitored as a function of incubation time using the dye thioflavin T, which binds to amyloid fibrils but not to ...

Accumulation of a protein called TDP-43 is a key feature of ALS and frontotemporal dementia. In a newly published study, researchers report ‘seeding’ this accumulation through fragments of the culprit ...

Alzheimer’s disease (AD) is a progressive neurodegenerative disorder, and researchers now attribute its symptoms to the deposition of tau amyloid fibrils. Although scientists developed many ...

Researchers have developed a laboratory model that mimics the pathological aggregation of TDP-43, a key protein in ALS and ...

This nuclear imaging technique is less invasive, but still requires injection of a radioactive tracer molecule (TC-PYP), which binds to amyloid fibrils and allows for their detection throughout ...

Amvuttra operates via RNA interference (RNAi), a groundbreaking technology that inhibits the production of the TTR protein in ...

By rapidly knocking down TTR production, vutrisiran decreases deposition of TTR fibrils, which form amyloid and cause irreversible cardiovascular damage and premature death in patients with ATTR ...