These fragments aggregate into amyloid fibrils, forming cellular inclusions that are hallmarks of HD pathology. The propensity of polyQ proteins to aggregate correlates with tract length, which ...

The kinetics of fibrillization in dilute aqueous solutions of the protein was monitored as a function of incubation time using the dye thioflavin T, which binds to amyloid fibrils but not to ...

View Full Profile. Learn about our Editorial Policies. Alzheimer’s disease (AD) is a progressive neurodegenerative disorder, and researchers now attribute its symptoms to the deposition of tau amyloid ...

This nuclear imaging technique is less invasive, but still requires injection of a radioactive tracer molecule (TC-PYP), which binds to amyloid fibrils and allows for their detection throughout ...

For each structural strain of tau fibrils, they identified amino acids without which the strain cannot form its signature ...

The Amyloid—Tangle Connection. Aβ aggregates (green) hyper-excite neurons in tau epicenters and connected regions, strengthening that connectivity. This pushes tau propagation from one region to ...

A novel wireless photothermal DBS nanosystem uses nanoparticles to target and restore damaged neurons in Parkinson’s disease, offering a non-invasive, precise, and safe alternative to traditional DBS.

Exercise may positively influence the interactions between brain cells in the hippocampus, a brain region involved in ...

that binds to the hydrophobic domain of the non-amyloid-β component of α-synuclein, facilitating the degradation of α-syn fibrils. Using an α-syn fibril-induced PD model, the researchers ...