Figure 1: Chemical structure of amides and the conventional chemical method for amide bond synthesis. Figure 2: Representation of protein and peptide synthesis by biochemical and chemical methods.

with an amino group (-NH(2)) -- a variety of different reactions have been developed for the formation of amide bonds. However, many of them are not broadly applicable due to a lack of ...

In an effort to improve the efficiency of N-acylation, or amide bond formation, of nitrogen-containing heterocyclic compounds, or cyclic compounds composed of nitrogen and one or more other ...

The study found that, out of a random selection of drug candidates, amide-bond formation was used in the synthesis of 84% percent of drug candidates. Partnering for commercial development The only ...

Even though amide bonds are everywhere—they hold proteins together and are essential components in many drugs—forging this molecular motif in a reaction flask can be challenging. For example ...

A platform to engineer enzymes responsible for the formation of amide bonds as an effort toward developing biocatalysts for green chemistry. Amide bonds — a type of chemical bond formed between a ...

The study found that, out of a random selection of drug candidates, amide-bond formation was used in the synthesis of 84% of drug candidates. The only theoretical by-product of amide formation is ...

The large subunit catalyzes the formation of amide bonds in a growing peptide or protein chain. A small collection of RNA molecules forms the core of the ribosome and is responsible for catalyzing ...

The molecules that served as substrates to help the formation of the amide bonds in the experiments are outgassed during volcanism and are all likely to have been present on the early Earth.

It would be very inconvenient.” Tim Cernak, assistant professor of medicinal chemistry and principal investigator of the study The common amide bond is formed by coupling an amine and a ...

The molecules that served as substrates to help the formation of the amide bonds in the experiments are outgassed during volcanism and are all likely to have been present on the early Earth.