Scientists have unlocked new details on important receptor proteins—promising targets for the creation of novel drugs for ...

Scientists have unlocked new details on important ‘receptor’ proteins –promising targets for the creation of novel drugs for ...

Geneva, Switzerland, May 12, 2025-Addex Therapeutics (SIX/NASDAQ: ADXN), a clinical-stage biopharmaceutical company focused on developing a portfolio of novel small molecule allosteric modulators for ...

We also compare available smoking cessation medications and other nAChR orthosteric and allosteric ligands that have been developed with emphasis on the difficulties faced in the development of ...

Looking for new developments in the field, we rely on the classic two-state Boltzmann model to devise a novel theoretical description of the allosteric modulation mechanism of membrane proteins in the ...

G protein-coupled receptors (GPCRs) are among the most promising drug targets. They often form homo- and heterodimers with allosteric cross-talk between receptor entities, which contributes to ...

and pharmacological intervention with allosteric ligands is desirable. In the case of AT1R, developing new generation of neutral, negative, or positive allosteric ligand therapeutics appears feasible ...

b. Two different agonists (ligands 2 and 3) promote a similar active state or conformation (R*), which binds the transducer (T1), but bias emerges through allosteric communication between the ...

The first class of drugs to demonstrate allostery were the benzodiazepines, which are allosteric ligands for a neurotransmitter γ-aminobutyric acid (GABA) receptor. Since then, many other ...