Scientists have unlocked new details on important receptor proteins—promising targets for the creation of novel drugs for ...

Allosteric ligands have been found to present a generally reduced side effect profile compared to orthosteric ligands but often suffer from reduced efficacy. (17,20) To overcome this problem, a new ...

† Department of Neuroscience and Pharmacology, Faculty of Health and Medical Sciences, The Panum Institute, University of Copenhagen, Blegdamsvej 3, Dk-2200 Copenhagen, Denmark ‡ Department of Physics ...

Contributed by J. Andrew McCammon, July 27, 2016 (sent for review June 24, 2016; reviewed by Richard J. Lewis and Jung-Hsin Lin) ...

For model benchmarking, Gcoupler was validated on GPCRs from the DUD-E dataset, alongside the information about the active ligands and their randomly selected number-matched decoys (35). Additionally, ...

Scientists have unlocked new details on important ‘receptor’ proteins –promising targets for the creation of novel drugs for ...

Explore GPCR-targeting therapies and their untapped potential in drug development, making up 30-35 percent of approved drugs.

Contributed by Russell A. DeBose-Boyd; received December 18, 2024; accepted April 11, 2025; reviewed by Peter Espenshade and Randolph Y. Hampton Mutations in the gene encoding UbiA prenyltransferase ...

For more than a century, carbon monoxide (CO) has been primarily studied as a toxic substance that interferes with oxygen delivery to tissue beds. This dogma has changed in recent years, whereby ...