Home; Articles; Rational Design of the Spatial Effect in a Fe(II)/α-Ketoglutarate-Dependent Dioxygenase Reverses the Regioselectivity of C(sp3)−H Bond Hydroxylation in Aliphatic Amino Acids ...

The aerobic oxidation of carbon-hydrogen (C-H) bonds in biology is currently known to be accomplished by a limited set of cofactors that typically include heme, nonheme iron, and copper. While ...

First, PHD3 deficiency or PHD3 prolyl hydroxylase activity–deficiency significantly improved glucose homeostasis in HFHS diet–induced diabetic mice. Furthermore, hydroxylation of CRTC2 was ...

Saturated tecovirimat , an antipox viral drug featuring a polycyclic hydrocarbon skeleton and an electron-deficient N-benzoamido moiety, underwent Mn(CF 3-PDP) 1 hydroxylation at the sterically ...

1 Department of Solar Materials, Helmholtz Centre for Environmental Research GmbH – UFZ, Leipzig, Germany; 2 Engineering and Technology, Bayer AG, Leverkusen, Germany; The implementation of ...

TxtC is an unusual bifunctional cytochrome P450 that is able to perform sequential aliphatic and aromatic hydroxylation of the diketopiperazine substrate thaxtomin D in two distinct sites to produce ...

TxtC is an unusual bifunctional cytochrome P450 that is able to perform sequential aliphatic and aromatic hydroxylation of the diketopiperazine substrate thaxtomin D in two remote sites to produce ...

The basic aliphatic glucosinolate molecules, methylthioalkyl (MT) GSLs, which contain only the core structure, may undergo a variety of secondary modifications such as oxidation, hydroxylation, or ...

Aldols from aliphatic aldehydes had been synthesized enantioselectively using Singh’s catalyst. Self and crossed aldol reactions with several linear aldehydes were performed. 1. Introduction The aldol ...