A "groundbreaking" cancer treatment trial by Memorial Sloan Kettering shows immunotherapy alone can eliminate some tumors, offering patients an alternative to chemotherapy and surgery.

Fewer Americans are dying from cancer, but rates rising in women and young people 01:56. The American Cancer Society's latest cancer report shows both positive and concerning trends: overall ...

Figure 4. Profiling levels of active ALDH proteins in breast cancer cell lines. (a) Mean fluorescence intensity (MFI) of ALDH activity measured in breast cancer cell lines using the ALDEFLUOR assay.

In 2020, research from the University of Liverpool Institute of Translational Medicine strongly suggested that alcohol use disorder (AUD, a.k.a. alcoholism) is an independent risk factor of lung ...

Alcohol-related liver disease puts you at risk of liver cancer. While the cause is not entirely known, the production of reactive oxygen species created by the breakdown of alcohol is known to damage ...

Here we describe a significant correlation of aldehyde dehydrogenase (ALDH) activity and the presence/absence of distant metastases in ten consecutive cases of human bone sarcomas. Additionally, ...

Alcohol can cause several different types of cancer, including breast, bowel, and liver cancers. Learn more about the link between alcohol and cancer and how to reduce the risk.

Epithelial–mesenchymal plasticity of cancer cells plays a pivotal role in tumor invasion, acquisition of stemness and metastasis ().Snail, ZEB, Twist, and FoxC2 are transcription factors that modulate ...

The aldehyde dehydrogenase (ALDH) superfamily of enzymes consists of 19 different human isoforms, which are NAD(P) +-dependent, that catalyze several cellular processes, including oxidization of ...

Figure 1 Detection of ALDH1 isoforms in ovarian cancer cell lines by Western blot analysis, and measurement of ALDH activity in TICs determined by ALDEFLUOR flow cytometry assay. Western blot analysis ...

In breast cancer, high ALDH activity is associated with overexpression of poly (ADP-ribose) polymerase 1 (PARP1) and Olaparib resistance . In addition, ALDH1A1 and 3A1 enzymes can contribute to ...

The notion of “cancer stem cells” or tumorigenic cells has been based on the observation that only a very small population of cells from a tumor can seed and form a tumor in severe combined ...