BMPER attenuated PI3K/AKT signaling and suppressed BMP4-driven smooth muscle activation in models of PAH. BMPER overexpression mitigated the vascular remodeling that characterizes pulmonary arterial ...

The AKT/PKB (protein kinase B) kinases, which include AKT1, AKT2, and AKT3, are key intermediates of signaling pathways that regulate cellular processes controlling cell size/growth, proliferation ...

The following is a summary of “ER-α36 prevents high glucose-induced cellular senescence and apoptosis in renal tubular cell,” ...

Patients with AKT pathway alterations obtained a similar PFS benefit. PFS assessment by blinded independent review yielded an even larger difference in the overall population (9.07 vs 3.71 months) and ...

2 The EGF signaling pathway regulates cell growth, proliferation, differentiation, and survival through the activation of EGFR and downstream cascades like RAS/RAF/MEK/ERK and PI3K/AKT.

As a consequence, phosphorylation of TCR proximal signaling molecules, including Lck and ZAP-70, is impaired (Panel A). Activation of the PI3K–Akt–mTOR pathway (Panel B) and activation of the ...

AKT pathway activation is implicated in endocrine-therapy resistance. Data on the efficacy and safety of the AKT inhibitor capivasertib, as an addition to fulvestrant therapy, in patients with ...