BMPER attenuated PI3K/AKT signaling and suppressed BMP4-driven smooth muscle activation in models of PAH. BMPER overexpression mitigated the vascular remodeling that characterizes pulmonary arterial ...

NUCKS1 regulates the invasion and metastasis of CRC via the HDAC2/AKT signaling pathway 蛋白质组学筛选出643个差异蛋白，其中HDAC2与NUCKS1表达呈正相关。机制研究表明，NUCKS1过表达使HDAC2和磷酸化AKT(p-AKT Ser473 ...

Investigating tirzepatide's role in Alzheimer's reveals its potential to improve brain function and reduce inflammation, ...

磷脂酰肌醇 3-激酶（PI3K）/蛋白激酶 B（AKT）/哺乳动物雷帕霉素靶蛋白（mTOR）通路是细胞内重要的信号传导通路之一，该通路的异常激活在多种疾病特别是恶性肿瘤中发挥着关键作用。近年来，靶向 PI3K/AKT/mTOR ...

The following is a summary of “ER-α36 prevents high glucose-induced cellular senescence and apoptosis in renal tubular cell,” ...

Such a cobblestone tongue is a telltale sign of a rare genetic condition called Cowden syndrome. It's caused by inherited ...

Research Progress on Signaling Pathways of LGALS1 in Malignant Tumors. Journal of Biosciences and Medicines, 13, 142-155. doi: 10.4236/jbm.2025.136013 . Malignant tumors, commonly referred to as ...

Kazia Therapeutics ( ($KZIA) ) just unveiled an update. On June 5, 2025, Kazia Therapeutics announced the dosing of the first patient in a Phase ...

This work demonstrates that oncogenic activation of the PI3K-AKT-mTOR signaling pathway suppresses ferroptosis via the sterol regulatory element-binding protein-mediated lipogenesis, and that ...

Here we show that IL-4 signaling co-opts the Akt-mTORC1 pathway to regulate Acly, a key enzyme in Ac-CoA synthesis, leading to increased histone acetylation and M2 gene induction. Only a subset of M2 ...