BMPER attenuated PI3K/AKT signaling and suppressed BMP4-driven smooth muscle activation in models of PAH. BMPER overexpression mitigated the vascular remodeling that characterizes pulmonary arterial ...

The following is a summary of “ER-α36 prevents high glucose-induced cellular senescence and apoptosis in renal tubular cell,” ...

NUCKS1 regulates the invasion and metastasis of CRC via the HDAC2/AKT signaling pathway 蛋白质组学筛选出643个差异蛋白，其中HDAC2与NUCKS1表达呈正相关。机制研究表明，NUCKS1过表达使HDAC2和磷酸化AKT(p-AKT Ser473 ...

Investigating tirzepatide's role in Alzheimer's reveals its potential to improve brain function and reduce inflammation, ...

磷脂酰肌醇 3-激酶（PI3K）/蛋白激酶 B（AKT）/哺乳动物雷帕霉素靶蛋白（mTOR）通路是细胞内重要的信号传导通路之一，该通路的异常激活在多种疾病特别是恶性肿瘤中发挥着关键作用。近年来，靶向 PI3K/AKT/mTOR ...

Hepatocellular carcinoma (HCC) is the most common primary liver cancer and a leading cause of cancer-related deaths worldwide ...

Such a cobblestone tongue is a telltale sign of a rare genetic condition called Cowden syndrome. It's caused by inherited ...

This valuable study presents a novel approach to enhance the therapeutic potential of mesenchymal stromal cells (MSCs) by genetically modifying their glycogen synthesis pathway, resulting in increased ...

The FDA approved taletrectinib for ROS1-positive NSCLC. The agent shows efficacy for both new and pretreated cases, including ...

Skeletal Muscle, Piceatannol, Energy Metabolism, SIRT1, Mitochondria Share and Cite: Tsuda, H. , Uchida, T. , Okuno, S. , ...