磷脂酰肌醇 3-激酶（PI3K）/蛋白激酶 B（AKT）/哺乳动物雷帕霉素靶蛋白（mTOR）通路是细胞内重要的信号传导通路之一，该通路的异常激活在多种疾病特别是恶性肿瘤中发挥着关键作用。近年来，靶向 PI3K/AKT/mTOR ...

NUCKS1 regulates the invasion and metastasis of CRC via the HDAC2/AKT signaling pathway 蛋白质组学筛选出643个差异蛋白，其中HDAC2与NUCKS1表达呈正相关。机制研究表明，NUCKS1过表达使HDAC2和磷酸化AKT(p-AKT Ser473 ...

PI3K/AKT 信号通路参与调节细胞的糖代谢 ... 图. BZA-enhanced 5-FU-induced cell apoptosis is partly related to the Bad/Bcl-2 signaling pathway in colon cancer HT29 and SW480 cells ...

The AKT/PKB (protein kinase B) kinases, which include AKT1, AKT2, and AKT3, are key intermediates of signaling pathways that regulate cellular processes controlling cell size/growth, proliferation ...

BMPER attenuated PI3K/AKT signaling and suppressed BMP4-driven smooth muscle activation in models of PAH. BMPER overexpression mitigated the vascular remodeling that characterizes pulmonary arterial ...

As a consequence, phosphorylation of TCR proximal signaling molecules, including Lck and ZAP-70, is impaired (Panel A). Activation of the PI3K–Akt–mTOR pathway (Panel B) and activation of the ...

AKT pathway activation is implicated in endocrine-therapy resistance. Data on the efficacy and safety of the AKT inhibitor capivasertib, as an addition to fulvestrant therapy, in patients with ...