Researchers from Northwest University in China developed a nano-composite hydrogel loaded with dexamethasone and kartogenin for osteoarthritis ...

A research team from Northwest University, China, has developed a breakthrough nano-composite hydrogel system to address the dual challenges of ...

Objectives: To explore potential T-cell epitopes of the core protein of human cartilage proteoglycan aggrecan (PG) in patients with rheumatoid arthritis (RA) or osteoarthritis. Methods: ...

在生物医学领域，超分子水凝胶因其独特的动态和可逆结构而备受关注，这些结构使其能够与生物分子进行特异性和可控的相互作用。这种水凝胶通过多种非共价相互作用（如氢键、π-π堆积、疏水相互作用等）组装而成，能够主动识别、捕获和释放生物分子，类似于细胞内外的生 ...

本研究针对关节软骨自我修复能力有限的临床难题，开发了基于人源诱导多能干细胞 (hiPSCs)的可扩展肢芽样间充质细胞 (ExpLBM)技术，成功制备颗粒状和板状软骨组织。通过小型猪异种移植实验证实，两种形态的工程化软骨均能有效整合并促进缺损修复，为软骨再生医学提供了新型可定制化移植策略。

BioMarin’s Voxzogo has been shown to increase growth rates in children with hypochondroplasia, a genetic cause of very short stature, in a phase 2 trial.

免疫荧光显示Cry使aggrecan和collagen II表达分别提升2.3倍和1.8倍，同时下调MMP13和ADAMTS-5表达40-50%。 SOX9作为关键转录因子，其表达水平经Cry处理后恢复至正常组78%。 动物实验验证治疗效果 大鼠模型中，Cry (50 μM)治疗8周使椎间盘高度指数 (DHI)提高37%，MRI灰度值提升2.1倍。

The progressive worsening of disc degeneration and related nonspecific back pain are prominent clinical issues that cause a tremendous economic burden. Activation of reactive oxygen species (ROS) ...

Nucleus pulposus (NP) tissue engineering has been demonstrated to be a feasible therapeutic strategy for intervertebral disc regeneration. In this study, we constructed a novel injectable biomaterial ...

Objectives In this study, we employ a multiomic approach to identify major cell types and subsets, and their transcriptomic profiles within the infrapatellar fat pad (IFP), and to determine ...