首先是组织透明化技术结合组织化学分析，通过这种方法，他们能够清晰地观察到小胶质细胞与 PNNs 在大脑中的空间关系；其次，利用免疫印迹技术，检测聚集蛋白聚糖（aggrecan）核心蛋白的表达水平；还采用了酶联免疫吸附试验（ELISA）定量分析透明质酸 ...

将免疫球蛋白 G（IgG）输送到关节软骨是一项挑战，这也给关节疾病治疗性抗体的开发带来了阻碍。在这项研究中，研究人员致力于通过与聚集蛋白聚糖（aggrecan，软骨基质中作为蛋白聚糖的关键成分）结合以及减小分子尺寸，来增强抗体在关节软骨中的渗透和 ...

aggrecan and versican. Indeed, there is evidence that, in many instances, these molecules are already chronically present in the tendon extracellular matrix (ECM) before an acute rupture. Our previous ...

IX71 型荧光显微镜（日本东京奥林巴斯公司）；MK3 型酶标仪（美国Thermo Fisher Scientific 股份有限公司）；BD-FACSVerse 型流式细胞仪（美国BD Bioscience 公司）；LSM700 型激光扫描共聚焦显微镜（德国蔡司集团）。 2.1.2供试品溶液的制备精密称取“2.1.1 ”项下牛膝多糖 ...

Solute carrier family 26 member 2 (SLC26A2) is an SO42− transporter, facilitating the uptake of inorganic sulfate into cells.

Objectives In this study, we employ a multiomic approach to identify major cell types and subsets, and their transcriptomic profiles within the infrapatellar fat pad (IFP), and to determine ...

A recent study examined a pattern of extracellular proteoglycans in the ECM of malignant brain tumors. The authors discovered that CS-modified proteoglycans, such as aggrecan, versican, neurocan, and ...

The nuclear factor of activated T cells (NFAT5), also known as a tonicity-responsive enhancer-binding protein, was originally identified as a key transcription factor involved in maintaining cellular ...

猬白鳐等软骨鱼类的关节表面上，科学家检测到了多种与润滑相关的分子标记物，如聚集蛋白（aggrecan）和透明质酸受体（CD44），这些物质能够在关节表面形成润滑层，减少摩擦，保障关节的正常功能。此外，研究人员还发现，猬白鳐的胚胎在关节发育过程中 ...

In their important manuscript, Costa et al. establish an in vitro model for dorsal root ganglion (DRG) axonal asymmetry, revealing that central and peripheral axon branches have distinct patterns of ...