Peripheral artery disease (PAD) is a common cardiovascular disease associated with increased risk of amputation, myocardial infarction, stroke, and death, as well as impaired quality of life (QOL), ...

G protein-coupled receptors (GPCRs) are a large family of seven-transmembrane proteins that can be activated by a diverse array of ligands, including hormones, neurotransmitters and sensory stimuli.

National Engineering Research Center of Novel Equipment for Polymer Processing, South China University of Technology, Guangzhou 510641, China ...

The authors apply Gcoupler to study the Ste2p-Gpa1p interface in yeast, identifying sterols such as zymosterol (ZST) and lanosterol (LST) as modulators of GPCR signaling. Our review will focus on the ...

Despite the central importance of G protein–coupled receptors (GPCRs) in drug discovery ... including primary cells relevant to a disease. Figure 1: Measuring cell type–dependent drug efficacy ...

kDivision of Pathology and Data Analytics, Leeds Institute of Medical Research at St James's University, University of Leeds, Leeds, UK ...