With the discovery that APP mutations can act as fully penetrant AD genes, a compelling hypothesis known as the amyloid cascade hypothesis was put forward. This hypothesis states in essence that ...

In autosomal-dominant AD, mutation type influenced amyloid-PET pegged to estimated years before symptom onset. Some mutations came with more striatal amyloid; some with cortical. CSF Aβ42 did not vary ...

32 Tau tangles and amyloid plaques are not the only features observed in the AD brain; inflammation and oxidative stress also occur. The mitochondrial cascade hypothesis indicates that tau and Aβ ...

The relationship held in three separate cohorts, and when using different ways to measure amyloid and tau. The findings hint that astrocytes drive tangle formation, the authors said. “GFAP positivity ...

"If you have more amyloid ... this graph it almost perfectly parallels the autopsy data. Our data are therefore consistent with the autopsy data suggesting that maybe 15 years before AD develops ...

Screening the literature, it may appear that for many in the AD field, the ultimate proof to be right after following the mainstream hypothesis (the "amyloid cascade") for decades is of top ...

It's hypothesized that in AD, amyloid triggers a cascade of events, starting with an increase in phosphorylation of tau, then accumulation of neurofibrillary tangles, with the amyloid and ...

A study led by the UK Dementia Research Institute (UK DRI) and University College London (UCL) has suggested targeting amyloid beta production in one cell type in the brain could improve early disease ...

Wang’s study “β-amyloid redirects norepinephrine signaling to activate the pathogenic GSK3β/tau cascade,” was recently published in Science Translational ... Our primary goal is to translate our bench ...