Insulin icodec is an acylated insulin analogue that makes it bind strongly to albumin in the body and have reduced affinity for insulin receptors, effectively creating an inactive reservoir that ...

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The ability of bacteria to control the biophysical properties of their membrane phospholipids allows them to thrive in a wide range of physical environments. Fatty acid biosynthesis is an energy ...

Diabetic kidney disease (DKD) is a prevalent complication of diabetes mellitus (DM), and its incidence is increasing alongside the number of diabetes cases. Effective treatment and long-term ...

It is acknowledged that copper ions cause cell death by binding to fat acylated proteins involved in the tricarboxylic acid (TCA) cycle, which results in mitochondrial injury and proteotoxic stress; ...

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Article subjects are automatically applied from the ACS Subject Taxonomy and describe the scientific concepts and themes of the article. As the whole society’s attention to environmental protection is ...

Revised: This Reviewed Preprint has been revised by the authors in response to the previous round of peer review; the eLife assessment and the public reviews have been updated where necessary by the ...

Unraveling the molecular identity of the mechanotransduction (MT) channel has long been regarded as the “Holy Grail” in hearing research. Recently, TMC1 and TMC2 (TMC1/2) have emerged as the ...