Although Activin/Nodal signaling regulates pluripotency of human embryonic stem (ES) cells, how this signaling acts in mouse ES cells remains largely unclear. To investigate this, we confirmed ...

Activin A在NEC模型小鼠肠道组织中表达上调 ELISA和WB显示NEC组Activin A蛋白水平显著高于对照组，免疫组化证实其定位在肠上皮和炎症浸润区域。 Activin A加剧NEC病理进程 ...

然而，在两种不同的神经病理性疼痛模型（EAE 和慢性压迫性损伤）中，TNFR2 激活后 CNP 的减轻依赖于性腺激素 Activin-A。 这表明性腺来源的因子通过一种共同机制影响 TNFR2 介导的疼痛缓解，且与性激素无关。

Supercede Therapeutics, Inc., a startup biotech company focused on small molecule drug development, today announced preclinical efficacy data from its lead therapeutic program to treat obesity.

Topline results were announced from a phase 3 study evaluating sotatercept-csrk in recently diagnosed adults with pulmonary arterial hypertension (PAH).

Activin A, FLRG, and PAI-1 levels vs disease severity in COVID-19 patients and in non-Covid 19 controls. A. Activin A (pg/mL) levels plotted for control, severe COVID-19, and critical COVID-19 ...

In muscle tissue, Activin interacts with the Activin RII receptor, triggering intracellular signaling pathways. Activin RII phosphorylates Activin RI, which activates the Smad2/3 signaling pathway.

Panelists discuss how riociguat targets the nitric oxide pathway and is approved for both Group 1 PAH and Group 4 chronic ...

In multiple cell-based assays, including studies on human adipocytes, the antibody has achieved complete blockade of Activin E-mediated signaling. Activin E plays a significant role in regulating ...

Inhibiting Activin E-mediated signaling could offer a novel therapeutic strategy to reduce internal abdominal fat while preserving muscle mass—potentially reversing obesity, ...