Although Activin/Nodal signaling regulates pluripotency of human embryonic stem (ES) cells, how this signaling acts in mouse ES cells remains largely unclear. To investigate this, we confirmed ...

Supercede Therapeutics, Inc., a startup biotech company focused on small molecule drug development, today announced preclinical efficacy data from its lead therapeutic program to treat obesity.

Topline results were announced from a phase 3 study evaluating sotatercept-csrk in recently diagnosed adults with pulmonary arterial hypertension (PAH).

In muscle tissue, Activin interacts with the Activin RII receptor, triggering intracellular signaling pathways. Activin RII phosphorylates Activin RI, which activates the Smad2/3 signaling pathway.

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection causes a "cytokine storm" in hospitalized and ICU patients. Studies have shown that the blockade of cytokine signaling and ...

Follistatin-344 (FS-344), a glycoprotein variant, has emerged as a focal point in scientific research due to its potential ...

Panelists discuss how riociguat targets the nitric oxide pathway and is approved for both Group 1 PAH and Group 4 chronic ...

Activin E is a therapeutic target for cardiometabolic disorders and obesity, linked to improved metabolic health through blocking its signaling. How does iBio’s Machine Learning Antibody Engine ...

In multiple cell-based assays, including studies on human adipocytes, the antibody has achieved complete blockade of Activin E-mediated signaling. Activin E plays a significant role in regulating ...

In-Licensing of novel activin E antibody underscores iBio’s commitment to delivering meaningful benefits to patients living with obesity and cardiometabolic diseasesSAN DIEGO, April 22, 2025 ...