Actin filament, one type of cytoskeletons, plays a central role in mediating cellular in responses to mechanical loading. Many mechanorgulation studies are restricted to 2D models using isolated cells ...

Actin filaments are protein fibers that make up the internal skeleton of the cell. As active elements of our cells, actin filaments support the cell’s fusion, movement and are involved in many other ...

Their approach involves strategically introducing mutations in a protein monomer to create disulfide bonds (S-S) between the building blocks of protein crystals at very specific sites. After isolating ...

As ABPs, the Arp2/3 complex binds with F-actin and nucleates a new filament from an existing actin filament. Arp2/3 complex deficiency induces excessive growth, exclusive axon branching, and loss of ...

Intracellular transport of critical cellular components (e.g. vesicles, organelles, mRNA, chromosomes) is accomplished by myosin Va molecular motors along complicated 3D networks of actin filaments.

When we combined 5 μM profilin–actin with concentrations of capping protein (200 nM) and Arp2/3 complex (50 nM) previously shown to promote rapid network growth (Loisel et al, 1999; Akin & Mullins, ...

Actin—the most abundant protein in most eukaryotic cells—assembles into a network of filaments that spans the length and breadth of the cell. Like the skeleton of an animal, this ‘actin cytoskeleton’ ...

Actin is one of the most abundant proteins in cells. It forms networks of filaments that provide structural support and generate the forces needed for cell movement, division, and many other processes ...