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Zestos verified that acetylcholine was inducing the pathway. As part of the method developed, Zestos came up with a way to separate the acetylcholine from other fat cells.

More information: Yukie Yamahashi et al, Phosphoproteomic of the acetylcholine pathway enables discovery of the PKC-β-PIX-Rac1-PAK cascade as a stimulatory signal for aversive learning, Molecular ...

Zestos verified that acetylcholine was inducing the pathway. As part of the method developed, Zestos came up with a way to separate the acetylcholine from other fat cells.

(2022) Phosphoproteomic of the acetylcholine pathway enables discovery of the PKC-β-PIX-Rac1-PAK cascade as a stimulatory signal for aversive learning. Molecular Psychiatry.

In researching neural pathways, it helps to establish an analogous relationship between a region of the human brain and the brains of more-easily studied animal species. New work from a team led ...

Acetylcholine (ACh) is a neuromodulator with a central role in aversive learning—rapid conditioning to unpleasant smell, taste, or touch. These learning functions play out in cells called D2 ...