The nicotinic acetylcholine receptors (nAChRs ... The acetylcholine (ACh)-binding sites on the nAChR are located in the extracellular domain at subunit boundaries, and their structure and drug ...

mouse model has long been used by immunizing mice with acetylcholine receptor from Torpedo fish (T-AChR), combined with complete Freund’s adjuvant (CFA). This mixture is administered via subcutaneous ...

Ltd. have synthesized azetidine-containing compounds acting as muscarinic M4 receptor positive allosteric modulators (PAMs) reported to be useful for the treatment of Alzheimer’s disease, asthma, pain ...

Department of Biochemistry and Molecular Biology, Indiana University School of Medicine, 635 Barnhill, Indianapolis, Indiana46202-3082, United States ...

This study presents a valuable finding on the role of cholesterol-binding site on GLP-1 receptors and functionally characterizes the impact of this mutation on receptor behavior in the membrane and ...

The study presents a valuable finding on the role of cholesterol-binding sites on GLP-1 receptors although the clinical ramifications are unclear and not eminent at this point. Based on the detailed ...

General disorders and administration site conditions include peripheral swelling ... Non-clinical studies have demonstrated that omadacycline inhibits the binding of the neurotransmitter ...

In the case of myasthenia gravis, the body produces autoantibodies that target acetylcholine ... antibodies disrupt receptor activity. "By mapping antibody binding sites on the receptor, we ...

In the case of myasthenia gravis, the body produces autoantibodies that target acetylcholine receptors ... directly disrupted the receptor’s function as an ion channel. The findings challenge previous ...

72076 Tübingen, Germany Tübingen Center for Academic Drug Discovery & Development (TüCAD2), 72076 Tübingen, Germany Interfaculty Institute of Microbiology and Infection Medicine (IMIT), University of ...

"The main issue with understanding these interactions is that there is a competition between an ion binding to a certain receptor and that same ion wanting to be surrounded by solvent molecules ...