The introduced acetyl group replaces an active hydrogen atom, resulting in an acetoxy group. There are two translational mechanisms that facilitate acetyl group attachment. These are either co- or ...

but the mechanisms regulating PDC activity—especially through post-translational modifications like acetylation—remain poorly ...

Simply put, higher levels of acetylation, shorten the effect of cortisol," explains Dr. Aishwarya Iyer-Bierhoff, the first author of the study. Elucidation of this regulatory mechanism opens up ...

Microtubule acetylation is essential for many cellular functions and has been linked to various health conditions, including cancer and brain disorders. Until this study, the molecular mechanism ...

However, the molecular mechanisms that underlie abnormal tau ... SIRT1 is a deacetylase, an enzyme that removes acetyl groups from proteins. Like phosphorylation, acetylation regulates many ...

when an acetyl group is transferred to the protein. The role of the 'driver' is played by enzymes, so-called acetyltransferases. Not much is known, however, about the precise mechanisms underlying ...

As they expected, Bub1 acetylation enhances its kinase activity, thereby promoting the phosphorylation of H2A. “This is the mechanism by which Bub1 acetylation regulates chromosome congression ...

A cable drum (consisting of four pairs of histones) ... The "read–write" mechanism by which cells replicate and use chemical instructions for expressing genes has been uncovered by RIKEN ...

"Because of these observations, we can confidently say that epigenetic mechanisms involving acetylation are essential to maintaining the fibrotic process in heart cells," Dr. Elrod said.