but the mechanisms regulating PDC activity—especially through post-translational modifications like acetylation—remain poorly ...

These enzymes can acetylate small molecules, metabolites, peptides, and proteins. This review presents current knowledge of acetylation mechanisms and functional implications in bacterial metabolism, ...

Simply put, higher levels of acetylation, shorten the effect of cortisol," explains Dr. Aishwarya Iyer-Bierhoff, the first author of the study. Elucidation of this regulatory mechanism opens up ...

Notably, H3 tail acetylation (e.g. K9ac, K14ac, K18ac) is linked to increased H3K4me3 engagement by the BPTF PHD finger, but it is unknown if this mechanism has a broader extension. Here, we show that ...

Find more information on the Altmetric Attention Score and how the score is calculated. The impact of Lys28 acetylation on Alzheimer’s Aβ peptide binding to the lipid bilayer has not been previously ...

as well as a mechanism involving p300-mediated acetylation of AFF1 and consequent inactivation of the super elongation complex. Soon after exposure to genotoxic reagents, mammalian cells inhibit ...

but instead on direct transfer of acetyl groups from the central metabolites acetyl coenzyme A or acetyl phosphate. Regardless of mechanism, most central metabolic enzymes possess lysines that are ...