[29] Although the pivotal role of antidesmoglein antibodies is widely accepted, little is known about the exact mechanisms through which they induce acantholysis. Upon a predisposing genetic ...

结论与展望 该研究首次证明Midostaurin通过多靶点调控：① 维持Dsg3膜定位；② 保护桥粒-角质纤维网络；③ 抑制促acantholysis（棘层松解）信号通路，从而有效对抗天疱疮自身抗体的致病效应。相较于传统免疫抑制疗法，这种直接加固细胞连接的治疗策略具有副 ...

The split due to acantholysis is in the suprabasilar level of the epidermis. In the erythematosus and foliaceus variants, erythema, crusting, and scaling are the major clinical findings ...

To determine the assembly pathway of desmoglein 3 (Dsg3) into desmosomes and the subsequent effects of pemphigus vulgaris immunoglobulin G (PV-IgG) on such, we employed a time-lapsed labeling for ...

Grace, A. P. , Stastna, M. , Lamb, K. G. , & K Scott, A. . (2022). Numerical simulations of the three-dimensionalization of a shear flow in radiatively forced cold ...

33 The binding between IgG and Dsg1 leads to disruption of the desmosomes located in the upper portion of the epidermis and loss of adhesion between the keratinocytes, a process known as acantholysis.

Specific dermatoses of pregnancy, according to the reclassification by Ambros-Rudolph et al. 8. Ambros-Rudolph et al. described two clinical presentations: the eczematous type (E-type) with a classic ...